"Baking Soda (Sodium Bicarbonate) mara guba kuma mara lahani an lulluɓe shi a cikin wani amintaccen 'capsule' nano (liposome), kuma ana ɗora tetracycline mai ƙarfin ɗaure ƙashi a saman don ya shiga saman ƙashi. Lokacin da osteoclasts ke lalata ƙashi ta hanyar fitar da acid, suna iya fitar da Sodium Bicarbonate nan take, yana hana aikin osteoclasts da cimma burin hana osteoporosis." Wata ƙungiya ƙarƙashin jagorancin Farfesa Shunwu Fan na Sashen Kula da Lafiyar Kashi, Asibitin Run Run Shaw, Jami'ar Zhejiang, da Farfesa Ruikang Tang na Sashen Kimiyyar Sinadarai, Jami'ar Zhejiang, kwanan nan sun buga bincikensu a cikin Journal of the American Chemical Society.
A cewar gabatarwar, osteoclasts suna kama da tururuwa a cikin bishiyar, a da suna aiki, har ma da tsayin bishiyar, amma kuma saboda lalacewa da faɗuwa na dogon lokaci. Nazarin da ake yi a yanzu ya yi imanin cewa babban dalilin osteoporosis shine kunna osteoclasts ba daidai ba, kuma ana ɗaukar fitar da acid daga osteoclasts a matsayin babban abin farko na lalata ƙashi ta hanyar osteoclasts da kuma abin da ake buƙata don lalata ƙashi.
Manyan magunguna a fannin maganin osteoporosis na asibiti suna cimma manufar hana shaƙar ƙashi da kuma haɓaka ƙashi ta hanyar mai da hankali kan daidaita ilimin halittar osteoclast ko osteoblast, amma ba sa kashe babban matakin farko na yanayin acid na waje na samuwar osteoclast daga tushen. Saboda haka, magungunan da ake da su na iya rage asarar ƙashi a cikin tsofaffi har zuwa wani mataki, amma sau da yawa ba za su iya mayar da lalacewar ƙashi gaba ɗaya da ta faru ba, kuma yin amfani da magungunan da ba ƙashi ba na zaɓi na iya haifar da wasu illoli masu guba na gabobi.
Bugu da ƙari, duk da cewa osteoclasts sune sanadin osteoporosis, bincike da yawa sun nuna cewa suna taka rawa wajen haɓaka samuwar ƙashi da kuma angiogenesis a matsayin "ƙwayoyin precursor" kafin su fitar da acid. Saboda haka, yana da matuƙar muhimmanci a hana osteoclasts daidai.
Tawagar Fan Shunwu da tawagar Tang Ruikang sun fara kai hari ga sinadarin Sodium Bicarbonate liposomes zuwa saman ƙashi, inda suka samar da wani tsari mai kariya daga alkaline, suka rage sinadarin acid da osteoclasts ke fitarwa, suka hana kunna osteoclasts yadda ya kamata, da kuma sake daidaita yanayin ƙashi don cimma tasirin maganin osteoporosis.
Lin Xianfeng, likitan ƙashi a Asibitin Run Run Shaw na Jami'ar Zhejiang, ya ce binciken ya gano cewa kayan alkaline liposome da muhallin acidic na osteoclasts sun haifar da yawan apoptosis na osteoclasts, kuma sun ƙara fitar da adadi mai yawa na vesicles na waje. "Yana kama da saitin dominoes, waɗanda ake tura su ɗaya bayan ɗaya kuma ana ƙara girman su mataki ɗaya bayan ɗaya don su yi tsayayya da lalata ƙashi da ƙarfin osteoclasts ke haifarwa gaba ɗaya."
Lokacin Saƙo: Janairu-27-2021